In this submission Amnesty International highlights concerns about issues in the USA related to the obstacles to implementation at the domestic level; the continued use of the death penalty; the use of lethal force by law enforcement; the prevalence of gun violence and the failure to protect the right to life; the failure to respect sexual and reproductive rights; the “targeted killing” program- violations of the right to life; the failure to protect the right to freedom of expression and peaceful assembly; discrimination and violations based on sexual orientation and gender identity; the failure to protect Indigenous women from gender-based violence and unlawful pushbacks, arbitrary detention, and ill-treatment against asylum seekers by US boarder and immigration authorities.