Native American activist Leonard Peltier has been imprisoned in the USA for over 46 years, some of which was spent in solitary confinement, serving two life sentences for murder despite concerns over the fairness of his trial. He has always maintained his innocence. Now 78 years old, he contracted COVID-19 in 2022 and suffers from several chronic health ailments, including one that is potentially fatal. Not eligible for parole again until 2024, his lawyers submitted a new petition for clemency in 2021. President Biden must grant Leonard Peltier clemency on humanitarian grounds and as a matter of justice.