The commencement of COVID-19 vaccination in most countries of Latin America and the Caribbean has brought hope to the most unequal region of the world, and one that has been hit harshly by the pandemic. Most countries in the region entered into lockdown with emergency decrees in mid-March 2020, and a year on continue to battle against infection rates that remain high. This report offers essential measures that must be adopted to guide vaccination in Latin America and the Caribbean. These recommendations are based on international human rights law that is binding for States. Many of them can be implemented immediately.