In this submission Amnesty International expresses concern about policies impacting refugees and asylum seekers; gun violence and criminal justice issues;. persistent human rights violations associated with the US government’s national security and counter-terrorism programs; attacks on sexual and reproductive rights and the lack of protection for the LGBTI community; high maternal mortality rates and levels of violence against indigenous women and girls. Amnesty International has updated this document to include human rights violations associated with the US government’s response to the COVID-19 pandemic. It also includes concerns on the policing of the nationwide protests that took place following the torture and extrajudicial execution of George Floyd by Minneapolis police officers, as well as on key death penalty developments from 2020.